Fatal agranulocytosis attributed to co-trimoxazole therapy.

Thrombophlebitis migrans following co-trimoxazole therapy.

We report an unusual and severe vasculitic disorder following co-trimoxazole, given orally for a urinary tract infection. The vasculitis was manifest solely as thrombophlebitis migrans and involving only veins without evidence of polyarteritis nodosa, or underlying malignancy.

Acute tubular necrosis following co-trimoxazole therapy.

Fatal asthma attributed to patent foramen ovale.

A 37 year old woman was admitted to the hospital with acute severe asthma, shortly followed by respiratory failure and circulatory arrest. Despite intensive cardio-pulmonary resuscitation, during which extreme arterial hypoxaemia persisted, the patient died. Postmortem examination revealed a patent foramen ovale, with a diameter of 1 cm. A severe right-to-left shunt, initiated by acute pulmonar...

Increasing resistance of Brucellae to co-trimoxazole.

Brucellosis is still a common disease in many developing countries, particularly among farm workers, abattoir workers, and veterinarians, as well as those who rear sheep and camels. Similarly, the disease is prevalent among those who are in the habit of drinking fresh unpasteurized camel or goat milk (4). In Saudi Arabia it contributes substantially to ill health and outpatient visits (3). In o...

Cholestatic jaundice due to co-trimoxazole.

A patient developed cholestatic jaundice following therapy with co-trimoxazole. Inadvertent re-challenge with the drug resulted in further clinical and biochemical deterioration, but complete recovery ensued on stopping this drug.